The Office of Research on Women's Health (ORWH) announces the availability of administrative supplements to support research highlighting the impact of sex/gender differences (or similarities) and/or sex and gender factors in human health and illness, including preclinical, clinical and behavioral studies. Of special interest are studies relevant to the molecular and cellular and systems biology bases of disease and pathophysiology, clinical presentation, and prevention and treatment of disease. The proposed research should address at least one objective from Goals 1 through 3 of the NIH Strategic Plan for Women's Health Research.